CISCO connect – 2018: from complex to simple

From Simple to Complex Compounds

Trichothecenes: From Simple to Complex Mycotoxins

As the world's population grows, access to a safe food supply will continue to be a global priority. In recent years, the world has experienced an increase in mycotoxin contamination of grains due to climatic and agronomic changes that encourage fungal growth during cultivation. A number of the molds that are plant pathogens produce trichothecene mycotoxins, which are known to cause serious hum...

The origin recognition complex: from simple origins to complex functions.

Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if not thousands of origins of replication and assemble multiple proteins or protein complexes at these sites. During S phase, these complexes are activated in a reproducible, temporal program to generate twice this nu...

Complex networks of interactions connect genes to phenotypes.

31 Sine, S.M. (1997) Identification of equivalent residues in the γ, δ, and ε subunits of the nicotinic receptor that contribute to α-bungarotoxin binding. J. Biol. Chem. 272, 23521–23527 32 Czajkowski, C. and Karlin, A. (1995) Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the δ subunit within 0.9 nm of the α subunit-binding site disulfide....

Complex Networks from Simple Rules

Complex networks are all around us, and they can be generated by simple mechanisms. Understanding what kinds of networks can be produced by following simple rules is therefore of great importance. This issue is investigated by studying the dynamics of extremely simple systems where a “writer” moves around a network, modifying it in a way that depends upon the writer’s surroundings. Each vertex ...